Reclast Results In Kidney Failure

Reclast is but one of several trade and chemical names for the drug who’s International Nonproprietary Name (INN, which is the official generic name for a medication as approved by the World Health Organization) is zoledronic acid or zoledronate. Other trade names under which it has been marketed include Aclasta, Zomera, and Zometa. In this article, to minimize the possibility of confusion, we will be using only the name Reclast, which is its trade name in the United States (Aclasta is the trade name in Australia). It belongs to a class of drugs called diphosphonates, which have been designed to prevent loss of bone mass. Doctors administer the drug intravenously.

Purpose of the drug

The primary purpose of Reclast is to treat osteoporosis, breast and prostate cancers, and multiple myeloma that have metastasized to the bones, causing them to weaken. Hypercalcemia of malignancy, which occurs when an excess of calcium builds up in the body and causes abdominal and bone pain, may also be treated with Reclast.

Reclast and kidney failure

Although Reclast is a beneficial drug that can serve its purpose well, it can also have harmful side effects– even when used properly. The FDA, for instance, has become concerned about the possibility of kidney failure, which, though it occurs only rarely, can be very serious. They have thus issued a risk-warning directed specifically at patients who already suffer from impairment of the kidneys or are taking other medications that can damage those organs. In January 2009 alone, two dozen cases of kidney failure, five of them fatal, were publicized, with another eleven deaths and nine injuries being reported over the next three months.

Creatinine monitoring

Because of this danger, the FDA has recommended that patients who are due to receive a Reclast injection be subjected to creatinine monitoring so that doctors can measure their kidney health and know whether it is safe to administer the drug. Creatinine is a waste product produced by the breakdown of muscle tissue and is filtered through the kidneys before being eliminated in the urine. Doctors usually measure creatinine levels through the blood test elimination method.

Sources:
http://www.webmd.com/osteoporosis/news/20110901/fda-osteoporsis-drug_ups-kidney-failure-risk
http://www.webmd.com/a-to-z-guides/creatinine-and-creatinine-clearance-blood-tests